Work

trans-Banglene as a neurotrophic agent

Year: 2025

Type: article

Abstract: To gain deeper insight into the cellular systems influenced by the neurotrophic small molecule, trans-banglene (t-BG), a global proteomic profiling approach was employed to identify protein expression changes upon treatment. The primary objective was to compare these changes with those induced by nerve growth factor (NGF), a well-characterized neurotrophic molecule that promotes neuronal survival, differentiation, and synaptic plasticity through TrkA receptor-mediated signaling. This study sought to determine whether t-BG exerts its effects through the NGF/TrkA axis or follows an alternative mechanism.

Source: Iowa Research Online (The University of Iowa)

DOI: 10.25820/etd.007815

Author: Wijesiri Gunawardana, Piyumi

Language: English

Topic: Nerve injury and regeneration

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6889570525

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