Preliminary investigation of Ru(II) complexes bearing nile red chromophores for photodynamic therapy
Year: 2025
Type: article
Abstract: Two previously investigated Ru(II) triplet photosensitisers (PS) ([Ru-2ENR][(PF6)2] and [Ru-3ENR][(PF6)2]) comprising a bipyridyl frame and acetylene appended Nile red chromophore, were converted to their chloride salts for cytotoxicity and phototoxicity measurements. SKBR3-cell lines were used to evaluate the photodynamic activity of the compounds. Irradiation ( λ ex 630 nm; 15 min; 33 J cm−2) at a non-toxic concentration of 10 nM, [Ru-2ENR][(PF6)2] and [Ru-3ENR][(PF6)2] induced a reduction in metabolic activity by 60% and 30% respectively.
Source: Frontiers in Chemical Biology
Authors: Claire Condon, Oriol Careta-Borràs, Judit Fodor, Amani B. Al Riyami, Xiao Xiao, Jianzhang Zhao, Carme Nogués, Sylvia M. Draper
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,353
OpenAlex ID: W6889798131