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Monocytes but not plasmacytoid dendritic cells show aberrant TLR8 signaling in patients with systemic sclerosis (SSc)

Year: 2024

Type: conference-paper

Abstract: Introduction: Systemic sclerosis (SSc) is a severe rheumatic disease, leading to inflammation and fibrotic tissue rearrangement of different organs like skin, lung, and heart. Increased type I interferon (IFN-I) signaling in blood and affected tissue was shown to mediate inflammation in SSc. Accordingly, [for full text, please go to the a.m. URL]

Source: German Medical Science (German Research Foundation)

DOI: 10.3205/24dgrh016

Authors: Graalmann, Theresa, Ehlers, Christine, Thiele, Thea, Bruns, Luzia, Ziegler, Annett, Kalinke, Ulrich, Schefzyk, Matthias, Witte, Torsten

Institutions: Medizinische Hochschule Hannover, Helmholtz Centre for Infection Research, German Center for Lung Research, Center for Experimental and Clinical Infection Research

Language: English

Topic: Systemic Sclerosis and Related Diseases

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6889975263

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