A case of umbilical pemphigus vulgaris
Year: 2024
Type: article
Abstract: A case of umbilical pemphigus vulgaris is reported. A 37-year-old female presented with a half-year history of repeated oral blood blisters and periumbilical itchy blisters. Dermatological examination revealed a demarcated annular irregular erosive surface covered with odorless white secretions on the umbilical area. But neither blisters nor erosions were observed in the oral mucosa. PDAI activity scores were 2 points. Pathological examination of skin lesion showed blisters in the basal layer and acantholytic cells in the epidermis, and lymphocytic infiltrations in the superficial dermis. Direct immunofluorescence revealed reticular deposition of IgG and C3 in the intercellular space of the spinous layer, without IgM and IgA depostion. The diagnosis was pemphigus vulgaris. Patient was treated with intramuscular injection of Methotrexate (10 mg) once, and oral methylprednisolone tablets at a dose of 24 mg once daily, in addition to calcium supplementation and topical applications of Halometasone and Sodium Fusidate Ointment. After the skin lesion was improved, the patient was discharged. No new lesions occurred during 6-month phone follow-up.
Authors: ZHENG Hang, XIE Yalin, SUN Cuicui, CHEN Wenjing, LIANG Yunsheng, CHEN Yongfeng
Institutions: Anhui Medical University, Southern Medical University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6891574555
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