Work

Role of non-coding RNAs in skin photoaging

Year: 2024

Type: article

Abstract: Skin photoaging, a phenomenon of premature skin aging due to prolonged exposure to ultraviolet (UV) radiation, manifests as wrinkles, loss of skin elasticity, pigmentation disorders, and age spots. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play a crucial role in regulating gene expression and the development of skin photoaging. This review summarizes the molecular mechanisms of specific ncRNAs (such as miR-34a, miR-134, miR-1246, lncRNA H19-miR-296-5p-IGF2, lncRNA PVT1-miR-551b-3p-AQP3, lncRNAMeg3-miR-93-5p-epiregulin, circ-COL3A1-859267 and circ-0011129) in skin photoaging. Additionally, the review discusses the potential application of ncRNA-based therapies in photoaging, as well as the current challenges and future research directions.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.3969/j.issn.1674-8468.2024.11.010

Authors: HE Zezhi, CHEN Jiazhen, WU Hui, SHEN Haojia, LI Runxiang, ZHU Huilan

Institutions: Guangzhou Institute of Dermatology, Guangzhou Medical University

Language: English

Topic: Skin Protection and Aging

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6891574977

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