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Research Advances on Circular RNA in Malignant Tumors of Digestive System

Year: 2025

Type: article

Abstract: Circular RNAs (circRNAs) are a class of single-stranded non-coding RNAs that form circular conformations through non-canonical splicing or reverse splicing events. Recently, aberrant expression of circRNA has been observed in several cancers. An increasing number of studies suggested that circRNA is involved in tumor suppression or tumor promotion to varying degrees through diverse molecular mechanisms, highlighting its key role in the occurrence and development of tumors. In this review, we systematically summarize the latest research progress on the function and molecular mechanism of circRNA in malignant tumors of the digestive system. circRNA is expected to be further explored as a target molecule in the treatment of digestive system cancers in the future.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.3971/j.issn.1000-8578.2025.24.1330

Authors: Yujuan JIANG, Yantao TIAN

Institution: Chinese Academy of Medical Sciences & Peking Union Medical College

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6891611119

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