Zebrafish Larvae Model for Prenatal Exposure to Valproic Acid: Autism Spectrum Disorder and Macrocephaly
Year: 2024
Type: dissertation
Abstract: Several biological attributes and key technologies make the zebrafish (ZF) model an effective system for understanding the brain and behavior. ZF are translucent, develop ex utero, readily absorb chemicals from the bath, and possess a relatively simple nervous system. Valproic acid (VPA) exposure is associated with neurodevelopmental disorders, such as autism spectrum disorder (ASD). VPA exposure in zebrafish phenocopies, in a species-specific manner, some of the behavioral symptoms observed in humans exposed to this chemical agent. As such, this study seeks to study VPA’s effects using the zebrafish model. Specifically, this study aims to examine VPA exposure’s anatomical effects (20 µM VPA) by investigating head size.
Author: Jaber, Lama
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6892956381
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