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Cisplatin-induced Renal Salt Wasting Syndrome

Year: 2024

Type: article

Abstract: This study examines the nephrotoxic effects of cisplatin, a platinum antineoplastic agent widely used in cancer treatment. Despite its efficacy against malignancies, cisplatin can induce apoptosis in the proximal tubule of the nephron, leading to a reduction in the glomerular filtration rate. The primary focus of this research is on hyponatremia as a potential side effect, with inappropriate antidiuretic hormone secretion syndrome (SIADH) and Renal Salt Wasting Syndrome (RSWS) being the main mechanisms. A case of RSWS is reported in a 34-year-old adult male following cisplatin chemotherapy for osteosarcoma cruris sinistra. Understanding the pathophysiological distinctions between SIADH and RSWS is crucial for proper management, as errors in diagnosis and therapy can exacerbate the patient's condition. RSWS therapy involves restoring intravascular volume through oral and intravenous fluids, along with correcting hyponatremia with saline. The patient demonstrated improvement after 12 days of treatment, offering valuable insights for similar conditions in patients undergoing cisplatin chemotherapy.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.13846116

Authors: I Made Dwi Payana, Ni Nyoman Mahartini, Sianny Herawati, Ni Kadek Mulyantari

Institution: Udayana University

Language: English

Topic: Electrolyte and hormonal disorders

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6893026752

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