A Review on Analytical Methods for Glibenclamide by Hplc
Year: 2024
Type: dissertation
Abstract: Glibenclamide, or glyburide, is a second-generation sulfonylurea that effectively lowers blood sugar in type-2 diabetes patients who do not require insulin. Symptoms of low blood sugar may include excessive thirst, fatigue, dizziness, increased hunger, and blurred vision. It should be used alongside a proper diet and exercise and can be combined with other diabetes treatments, but is not suitable for type-1 diabetes. Common side effects include nausea, heartburn, weight gain, and bloating, with a notable risk of hypoglycemia and angioedema. Its use is generally discouraged during pregnancy but may be acceptable while breastfeeding. Glibenclamide stimulates insulin secretion from the pancreas and is contraindicated in patients with sulfonamide allergies, type-1 diabetes, ketoacidosis, or severe renal or hepatic impairment. This article also discusses validated analytical techniques, particularly High Performance Liquid Chromatography (HPLC), for quantifying Glibenclamide in pharmaceutical formulations. Key words: Glibenclamide, HPLC, Accuracy, Precision, ICH, Validation
Author: Banothu Bhadru*, Tadikonda Rama Rao, Sappidi Harshitha
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6893051870
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