Review on a Thermodynamically Stable Nanolipoidal Drug Delivery System
Year: 2024
Type: article
Abstract: The poor pharmacokinetics of many pipeline medication candidates prevent them from ever reaching the market. The progressively low bioavailability of the recently studied New Molecular Entities (NMEs) is one such obstacle in the medication development process. Formulators frequently use the nano-lipoidal colloidal system, which creates micro-emulsions and nano-emulsions as drug delivery vehicles for BCS Class II, III, and IV medications, as a promising platform to address such bioavailability problems. Owing to the coexistence of surfactants and hydrophilic and lipophilic domains, these nano lipoidal colloids demonstrate superior drug solubility and permeability across biological environments. Micro-emulsions are mixtures of water, oil, and surfactant plus a co-surfactant that are isotopically transparent and thermodynamically stable. Micro-emulsions can reduce patient variability in pharmacokinetics and therapeutic action, protect labile drug ingredients, control drug release, increase drug solubility, increase absorption followed by bioavailability, reduce medication dose and limit toxicity. The devices can be utilized as Self-Micro-emulsifying Drug Delivery Systems (SMEDDS) to provide medication orally in order to prevent drug hydrolysis while being stored and to minimize bulk.
Author: Saiyedselimali*, Pintukumar De, Abdus Samad
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6893061957
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