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Chronic Sodium Valproate Intake to Treat Epilepsy Inducing Hyperammonaemia Encephalopathy

Year: 2024

Type: article

Abstract: Sodium valproate, frequently prescribed as an antiepileptic, can cause encephalopathy secondary to hyperammonia, even after chronic use. We report the case of a 75-year-old patient with Parkinson's disease and epilepsy presenting a coma without deficit, with a normal cerebral morphological work-up, an electroencephalogram ruling out status epilepticus, a cerebrospinal fluid culture ruling out neuromeningeal infection, and a normal metabolic work-up apart from hyperammonia explained by sodium valproate intake.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.14909937

Author: *Rida Touab, Tareq Baadi, Marouane Jidal, Ayoub Bouayda, Abdelhamid Eljaafari, Hicham Balkhi

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6893064322

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