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Neurofibromatosis type 1 and High-risk Pregnancy: A Case Report

Year: 2024

Type: article

Abstract: Introduction: A high-risk pregnancy is the result of a disease present before pregnancy. Neurofibromatosis type 1 is a rare disease during pregnancy, autosomal dominant, with a mutation in the NF1 gene, on chromosome 17q11.2. Clinical case: 38-year-old woman, Gestational age 1. Mother with neurofibromatosis type 1. The patient is hypertensive, diagnosed 7 years ago and currently treated with alpha-methyldopa 250 mg every 12 hours orally. She reports the diagnosis of neurofibromatosis type 1 since childhood. Without adequate prenatal control, with alterations in the Doppler ultrasound and complication of intrauterine growth restriction stage 1. A referral is made to third level of care and evaluation by maternal-fetal medicine Discussion: Pregnancies in patients with neurofibromatosis are predisposed to obstetric complications due to the multisystemic nature of the disease. These patients have a higher incidence of spontaneous abortions, stillbirth, preeclampsia, intrauterine growth restriction (IUGR), oligohydramnios, premature birth and cerebrovascular complications.

Source: International Journal of Medical Science and Clinical Research Studies

DOI: 10.5281/zenodo.14272565

Authors: Orlando Jesus Sarmiento Haydar, Catalina Ivonne Chan Sierra, Juan Carlos Cachón Alpuche, Manuel Andrés Miranda Guillermo

Institutions: Autonomous University of Yucatán, Institute for Social Security and Services for State Workers

Language: English

Topic: Neurofibromatosis and Schwannoma Cases

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W6893137331

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