A Review Article on Novel Transdermal Drug Delivery System
Year: 2024
Type: article
Abstract: Transdermal Drug Delivery System is controlled medicated that is set on the skin to deliver a particular Portion of medicine through the skin and into the circulatory system. It is likewise significant because of its Interesting benefit such as less absorption, more uniform plasma levels, improved bioavailability, decrease Side effect, efficacy and quality of the product. Transdermal dose structures may give clinicians a chance to Offer more therapeutic alternatives to their patients to upgrade their consideration. For thousands of years, human civilizations have applied substances to the skin as cosmetic and medicinal agents. However, it Was not until the twentieth century that the skin came to be used as a drug delivery route. In fact, Merriam Webster dates the Word “transdermal” to 1944 highlighting that it is a relatively recent concept in medical and pharmaceutical practice. Transdermal drugs are self‐contained, discrete dosage form. Drug delivery through the skin to achieve a systemic effect Without producing any fluctuations in plasma concentration of the drug. Topical administration of therapeutic agents offers Many advantages over conventional oral and invasive methods of drug delivery. And also provide controlled release of the Drug for extended period of the time. Today about 74% of drugs are taken orally and are found not to be as effective as desired. To improve such characters transdermal Drug delivery system was emerged. The transdermal route of drug delivery has attracted researchers due to many biomedical Advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for Successfully delivering drug molecules to the systemic circulation by this route. Drug delivery through the skin to achieve a systemic Effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. The Development of transdermal drug delivery systems is a multidisciplinary activity that encompasses fundamental feasibility studies Starting from the selection of a drug molecule to the demonstration of sufficient drug flux in an ex vivo and/or in vivo model the Fabrication of a drug delivery system that meets all the stringent needs that are specific to the drug molecule (physicochemical and Stability factors), the patient (comfort and cosmetic appeal), the manufacturer (scale-up and manufacturability), and most Important, the economy.
Author: Rutik Kachare, Ulka Mote
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6893141996
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