Synthesis, and biological evaluation of novel 2-(3-(5-cyano-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenoxy)acetic acid as potential in vivo anti-inflammatory agent
Year: 2025
Type: article
Abstract: : Novel target compound, 2-(3-(5-cyano-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenoxy)acetic acid 2, was synthesized and evaluated for its anti-inflammatory activity using carrageenan-induced rat paw edema method in comparison with the selective COX-2 inhibitor, celecoxib. The results suggested that compound 2 proved good potency with edema inhibition rates of 22.28 and 25.23% at the third and fifth hours, respectively. More SAR study and optimization are warranted for compound 2, which has the potential to be employed as oral anti-inflammatory drugs. Keywords: Cyanopyridine; Anti-inflammatory; COX; Cyclooxygenase enzymes; Selective COX-2. Title: Synthesis, and biological evaluation of novel 2-(3-(5-cyano-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenoxy)acetic acid as potential in vivo anti-inflammatory agent Author: Alshimaa Kh. M. Ahmed, Mamdouh F. A. Mohamed, Eman A. M. Beshr International Journal of Novel Research in Life Sciences ISSN 2394-966X Vol. 12, Issue 2, March 2025 - April 2025 Page No: 1-8 Novelty Journals Website: www.noveltyjournals.com Published Date: 05-March-2025 DOI: https://doi.org/10.5281/zenodo.14974196 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/Synthesis,%20and%20biological%20evaluation-05032025-2.pdf
Authors: Alshimaa Kh. M. Ahmed, Mamdouh F. A. Mohamed, Eman A. M. Beshr
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6893201697
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