The Emerging Role of Zebrafish in Pre-Clinical Research
Year: 2025
Type: article
Abstract: Human safety incidents during trials come at a high cost. By following safety testing protocols, many of these can be avoided. Unfortunately, toxicity problems in the early phases of a drug development program can still be caused by a variety of variables. The zebrafish model can be continuously improved to start the creation of novel medications and methods for treating illnesses. Numerous scientific questions can be effectively addressed using the vertebrate model. It has been extensively employed in the research of disease biology and medication toxicity. Numerous methods frequently employed in zebrafish breeding labs have been recognized for their positive effects on the physiology and wellbeing of the animals. Nonetheless, information sharing amongst many institutions can increase the reproducibility of these findings. The ranges of husbandry parameters that are most likely to be suitable and successful for zebrafish are provided by standardization protocols. The model's benefits and drawbacks are also covered in the review. It examines the model's many facets and possible applications.
Author: Rudrakshri Kaushik1, Vivek Srivastava*1, Alok Kumar Shukla2
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6893215769
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