Role of Calcitonin Peptide Precursor and C Reactive Protein in Excluding Associated Co-infection in Patients With Viral Pneumonia Admitted to ICU
Year: 2025
Type: article
Abstract: Background: Bacterial infection and a non-infectious inflammatory response require a refined distinction for clinical reasoning to be effective. [Calcitonin Peptide Precursor - Procalcitonin (PCT)] and C-reactive protein (CRP) have received considerable attention as inflammatory markers; however, the extent of their competitive diagnostic value, especially in the presence or absence of co-infections, remains fully explored. Methods: This retrospective observational study took account of PCT and CRP levels in 100 patients, fifty of whom had co-infections. Data were processed through non-parametric tests, including the Wilcoxon Signed-Rank Test within groups and the Mann-Whitney U Test across groups. Results: The Wilcoxon Signed-Ranks Test confirmed substantial decreases in PCT and CRP levels post-infection (Z = -6.125, p = .000 and Z = -6.154, p = .000, respectively), signifying the scale of their change. The Mann-Whitney U Test also confirmed the relevance of the investigated biomarkers, as within the group of patients with active infection, both PCT and CRP were significantly raised (PCT: U = 22.000, p = .000; CRP: U = .000, p = .000). The strength of the association between the biomarkers was measured using Spearman’s correlation. Conclusion: Group comparisons demonstrated significant reductions in PCT and CRP from initial to follow-up measurements. A comparison between the groups showed that the co-infection group had significantly higher levels of both PCT and CRP. Weak statistically non-significant correlations were observed between PCT and CRP. PCT and CRP levels were significantly higher in co-infected patients, indicating that these markers may be useful in cognitively diagnosing and monitoring infections. Additional studies are necessary to formulate appropriate diagnostic frameworks.
Authors: Omar, Abdulmabod, Alwaseef, Mohammad AbdElhameed, Ebrahim Shaheen, Mohammed Abdelmoaty, Ewis, Ahmed M, Youssef, Ibrahim H, Elhameed Khedr, Muhammad Abd, Salah Elsawy, Ahmed Gamal, Aly Said, Salwa Rashad, Ali Alhangor, Ali Fawzy, Ali, Wagenat E, Abdelsamad, Ahmed Mohamed, Attia, Asmaa A, Elsayed, Mostafa Mohamad, Adawy, Zeinab, Ahmed, Laila A, Ahmed Mahrose, Hany Kamal, Mohammed Metwally, Mahmoud Mohammed, Mahmoud Elsayed, Bassam Abdellatif, Newishy, Hatem Mohamed, Elsaid Radwan, Enas Elsebaee, Abozeed, Ahmed Abdelhameed, Ageel, Mohammed Abdulgadir, Hussein, Naema R, Mahmoud, Ibrahim Fadl, Abdelmottaleb, Neazy Abdelmokhles
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W6893240212
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