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Formulation and Evaluation of Tacrolimus Transdermal Gel

Year: 2025

Type: article

Abstract: Formulation and evaluation of Transdermal gels of Tacrolimus, ant psoriasis drug, to circumvent the first pass effect and to improve its bioavailability with reduction in dosing frequency and dose related side effects. Twelve formulations were developed with varying concentrations of polymers like Carbopol 934P, HPMCK4M and Sodium CMC. The gels were tested for clarity, Homogeneity, spread ability, Extrudability, Viscosity, surface pH, drug Content uniformity, in-vitro drug diffusion study and exvivo permeation study using rat abdominal skin. FTIR studies showed no evidence on interactions between drug, polymers and excipients. The best in-vitro drug release profile was achieved.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.15615026

Author: Shital Chavan*, Priti Ambhore

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6893294452

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