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Biological Effects and Clinical Implications of Acute Radiation Syndrome

Year: 2025

Type: article

Abstract: Acute Radiation Syndrome (ARS) arises from the exposure of humans to high doses of ionizing radiation over a short period. This review synthesizes current knowledge on the pathophysiology, dose–response relationships, and organ-specific manifestations of ARS. Emphasis is placed on the mechanisms of DNA damage—both direct ionization and indirect free radical formation—and how linear energy transfer (LET) influences cellular outcomes. We also examine clinical findings across the hematopoietic, gastrointestinal, nervous, respiratory, and integumentary systems, as well as current approaches to diagnosis, supportive care, and emerging therapeutic strategies.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.15493875

Authors: To'xtasheva Zuhra Alisherovna, To'xtasheva Fotima Alisherovna, Sattorov Y.K

Language: English

Topic: Effects of Radiation Exposure

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6893305319

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