Formulation And Evaluation of Polyherbal Nutraceutical Tablet
Year: 2025
Type: article
Abstract: This research focuses on the creation and assessment of immediate release tablets containing Nateglinide, a medication used to treat Type 2 diabetes mellitus. These formulations are designed to dissolve quickly, ensuring rapid drug release, which enhances patient adherence and therapeutic effectiveness. Nateglinide tablets were produced using the wet granulation method, incorporating various excipients, such as starch, lactose, and sodium starch glycolate. A total of six formulations (F1–F6) were developed and assessed for both pre-compression and post-compression characteristics, including angle of repose, bulk density, hardness, friability, thickness, weight variation, disintegration time, and in vitro drug release. Among these, formulation F2 demonstrated the most advantageous properties, with a rapid disintegration time of 13.3 min and the highest cumulative drug release of 87.16% within 60 min. The compatibility between the drug and excipients was verified using FTIR and DSC analyses. Stability tests showed no significant changes in drug release over the month. These findings indicate that the optimized formulation is a promising strategy for achieving immediate therapeutic effects with nateglinide.
Author: Dr. Ganesh Tolsarwad*, Rohini Holkunde, Shripad Ahankari, Sunil Dongre, Gavhane Rajendra
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6893334230
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