Tacrolimus: An Updated Review on Pharmacological, Pharmacodynamic, Pharmacokinetic Profile and Pharmacogenomics
Year: 2025
Type: article
Abstract: Tacrolimus is a commonly prescribed immunosuppressant medication for prevention of organ transplant rejection. After organ transplantation, most of the patients are discharged and prescribed with tacrolimus medication due its high immunosuppressive efficacy. Although, tacrolimus is a go-to medication for the organ transplantation, it comes with numerous challenges such as narrow therapeutic index, high intra and interpatient variability in pharmacokinetics and the associated adverse effects. Therefore, it creates major difficulties for the clinicians by making the regular therapeutic drug monitoring and dose adjustment necessary. This review highlights various aspects including pharmacokinetics, food and drug interactions and genetics which are critical to understand the risk factors associated with tacrolimus and the measures required to overcome them. In particular, the information on human pharmacokinetics of tacrolimus would assist in further dose optimization with the defined pharmacokinetic-pharmacodynamic relationship.
Author: Sajad Khaliq Dar1,2, Arshad H. Khuroo1, Mohd. Akhtar*2, Sudershan Kumar1, Chandni Sharma3
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6893334901
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