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Genetic Structure of Acute Myeloid Leukemia

Year: 2025

Type: article

Abstract: Acute myeloid leukemia (AML) - is the most common acute leukemia among adults. The pathophysiology of the disease is associated with cytogenetic abnormalities, gene mutations and aberrant gene expression. Molecular genetic features of AML underlie the stratification of patients into risk groups and determination of treatment tactics. Chromosomal aberrations such as t(6;9)(p23;q34.1), DEK:NUP214, translocations involving the KMT2A gene (MLL), mutations in the RUNX1, TP53, ASXL1 genes are factors of unfavorable prognosis.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.15384525

Author: EGAMOVA, SITORA KOBILOVNA

Institution: Bukhara State Medical Institute named after Abu Ali ibn Sino

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6893342351

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