Formulation and Evaluation of Agele Marmelos Lozenges
Year: 2025
Type: article
Abstract: The present study focuses on the formulation and evaluation of herbal lozenges containing Aegle marmelos extract, a medicinal plant known for its anti-diarrheal, antimicrobial, and anti-inflammatory properties. Lozenges were prepared using the wet granulation method, incorporating suitable excipients such as binders, sweeteners, and flavoring agents to enhance palatability and patient compliance. The formulated lozenges were evaluated for various physicochemical parameters including weight variation, hardness, friability, drug content uniformity, disintegration time, and in vitro dissolution profile. Results demonstrated that all batches met the pharmacopeial standards, with optimized formulations exhibiting satisfactory mechanical strength, acceptable organoleptic properties, and sustained release of the herbal extract. The study concludes that Aegle marmelos lozenges offer a promising natural remedy for gastrointestinal ailments with improved ease of administration and enhanced therapeutic efficacy. The present research work involves the formulation and evaluation of herbal lozenges containing Aegle marmelos extract, a well-known medicinal plant traditionally used in Ayurvedic medicine for the treatment of various gastrointestinal disorders, especially diarrhea and dysentery. The objective was to develop a convenient and palatable dosage form that delivers the therapeutic benefits of Aegle marmelos in a sustained and patient-friendly manner. Lozenges were prepared using the wet granulation technique, incorporating suitable excipients such as sucrose, glucose, and natural flavors to improve taste and texture, along with binders and lubricants to ensure proper tablet formation. Multiple formulations were developed and subjected to comprehensive evaluation, including physical characteristics like hardness, thickness, friability, and weight variation, as well as pharmaceutical tests such as disintegration time, content uniformity, and in vitro drug release. Among the prepared batches, the optimized formulation showed satisfactory organoleptic properties, adequate mechanical strength, uniform drug content, and a controlled release profile over a specified time period. The results indicated that the formulated lozenges can effectively deliver Aegle marmelos extract in a stable, easy-to-administer form with improved patient compliance. This study supports the potential use of herbal lozenges as a novel dosage form for delivering natural plant-based remedies with therapeutic benefits
Author: Riteek Raghuwanshi*1, Nandakishor Deshmukh2, Dr. Swati Deshmukh3, Prajwal Raghuwanshi4, Chetan Bajare4, Shivani Wankhede4
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6893359928
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