Infrared Micro-spectroscopy as a Diagnostic Tool for Amyloidosis Subtype Identification
Year: 2025
Type: article
Abstract: The aim of this study was to assess the use of Synchrotron Radiation Fourier Transform InfraRed micro spectroscopy (SR micro-FTIR) in the diagnosing and subtyping of different misfolded proteins in various tissues and organs. To this end, specimens from various organ sites were investigated. Multivariate data analysis was applied to correlate the spectral datasets with histological and immunohistochemical findings and clinical data. The results of the study reveal significant segregation of tissues affected by amyloidosis and controls, but the observed amount of amyloid β-sheet did not correlate with the disease state. Amyloid light-chain type specimens contained more βsheet structures than non-Amyloid a types, and Tran’s thyretrin type showed very little. The Insulin type behaved differently
Author: Sofia, Marie van der Berg
Institution: University Medical Center Groningen
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6893394647
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