Formulation and Evaluation of Metformin HCL Gastroretentive Floating Sustained Released Tablet
Year: 2025
Type: article
Abstract: The Metformin HCl Gastroretentive Floating Sustained Release Tablet was formulated using the Wet Granulation method. This tablet incorporates an effervescent system, where Hydroxypropyl Methylcellulose (HPMC) K 100, a swellable polymer, facilitates the floating mechanism. Sodium bicarbonate is employed to create the effervescent system. A synergistic combination of HPMC K 100 and Xanthan Gum enhances the sustained release profile of the formulation. The prepared gastroretentive floating tablets were evaluated for various pharmaceutical parameters, including bulk density, tapped density, angle of repose, Carr’s index, weight variation, friability, and in vitro dissolution studies, along with the total floating time. The results from the optimized batch were satisfactory, indicating favorable flow properties. Both weight variation and friability were within the pharmacopoeial limits. In vitro dissolution testing revealed a maximum drug release of 99.10% within 8 hours.
Author: Abhishek Bhosale*1, Priti Shinde2
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6893397515
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