Sesquiterpenoid isolated from Colletotrichum truncatum derived from Gynura japonica: isolation, structure elucidation, and biological activity
Year: 2025
Type: article
Abstract: The aim of this research was isolation, structure elucidation, and biological activities of terpenoids from endophytic fungus obtained from G. japonica. An endophytic fungus, Colletotrichum truncatum, was isolated from the roots of G. japonica. C. truncatum was cultivated and extracted to give the crude extract. The crude extract was fractionated using vacuum liquid chromatography followed by separation and purification with column chromatography to obtain a terpenoid derivative (12.8 mg). The compound was characterised for its structure using FT-IR and NMR spectra. Based on spectral analysis, the isolated compound was identified as sydonic acid. The isolated sydonic acid was active against three tested bacterial strains and also demonstrated antioxidant activity with an IC50 value of 76.5 ± 0.93 μg/mL. Interestingly, chemical research on the terpenoid derivative from the fungus C. truncatum associated with G. japonica is first reported herein.
Source: Figshare
Authors: Riga Riga, Wandi Oktria, Ahadul Putra, Suryelita Suryelita, Adnan Luthfi Agusta, Okta Suryani, Sri Benti Etika, Bali Yana Fitri, Melindra Mulia, Edi Nasra, Desy Kurniawati, Khairil Arif, Dewi Meliati Agustini
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6902211605
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