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Additional file 1 of The phosphatase PPM1F, a negative regulator of integrin activity, is essential for embryonic development and controls tumor cell invasion

Year: 2025

Type: article

Abstract: Additional file 1: Figure S1 indicates similar size and brain histology of PPM1F ± mice compared to their wildtype littermates. Figure S1: Related to Fig. 3. Ppm1f ± adult mice have similar brain size and brain histology compared to their wildtype littermates. (A) Individual brain homogenates from 3–4 months old male wildtype PPM1 + / + and PPM1F ± mice were probed by Western blotting with antibodies against murine PPM1F (upper panel) or tubulin (lower panel). (B) Body weight of mice as in (A). Shown is mean ± s.e.m; n = 5; unpaired t-test, ns: not significant. (C) Brains of mice in (A) were isolated, weighted, and photographed. Scale bar: 1 cm (D) Coronal brain sections of PPM1 + / + and PPM1F ± mice were stained with cresyl violet. Lower panels show magnifications of the indicated, boxed cortical areas.

Source: Figshare

DOI: 10.6084/m9.figshare.29368167

Authors: Grimm, Tanja M., Dierdorf, Nina I., Herbinger, Marleen, Baumgärtner, Sarah, Sontowski, Erik, Paone, Christoph, Baade, Timo, Hauck, Christof R.

Institution: University of Konstanz

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6902220623

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