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Additional file 2 of Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer

Year: 2025

Type: article

Abstract: Additional file 2 (Fig. S2 Validation screen of top five QPOP-ranked drug combinations. a Single drug and combination dose response curves of QPOP-derived top-ranking drug pairs across (i) WT and (ii) RR FaDu, with accompanying b Fa-CI (fraction affected-combination index) plot. Combination indices of log(CI) <0 across a range of effect sizes (Fa) is indicative of a synergistic interaction. Data presented as means ± SD of two technical replicates.)

Source: Figshare

DOI: 10.6084/m9.figshare.28192175

Authors: Chan, Sharon Pei Yi, Yeo, Celestia Pei Xuan, Hong, Boon Hao, Tan, Evelyn Mui Cheng, Beh, Chaw Yee, Yeo, Eugenia Li Ling, Poon, Dennis Jun Jie, Chu, Pek Lim, Soo, Khee Chee, Chua, Melvin Lee Kiang, Chow, Edward Kai-Hua

Institutions: National University of Singapore, National Cancer Centre Singapore, Duke-NUS Medical School

Language: English

Topic: Histone Deacetylase Inhibitors Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6902225568

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