lncRNA GAS 5 rs145204276 as a risk factor for primary immune thrombocytopenia in the Chinese Han population
Year: 2025
Type: article
Abstract: Recent studies suggest that long noncoding RNA (lncRNA) GAS 5 plays a crucial role in the pathogenesis of primary immune thrombocytopenia (ITP). Identification of genetic variations affecting GAS 5 expression may provide insights into ITP mechanisms. This study aimed to explore the association between GAS 5 variants rs145204276 andrs55829688 and ITP risk in a Chinese Han population. The genotypes of rs145204276 and rs55829688 were analyzed in 302 ITP patients and 300 age-matched healthy controls. GAS 5 expression levels were quantified using quantitative real-time PCR (qRT-PCR) in both groups. Significant differences in allele and genotype frequencies of rs145204276 were observed between ITPpatients and healthy controls. Specifically, the deletion allele of rs145204276 was associated with a reduced risk of ITP and higher GAS 5 expression inpatients. However, no significant association was found for rs55829688 in any analysis. The rs145204276polymorphism in GAS 5 is significantly associated with ITP susceptibility and may serve as a potential biomarker for ITP prevention and treatment.
Source: Figshare
Authors: Liang, Ting, Yi, Hong, Guo, Huanyu, Xie, Yingjie, Hu, Jianhua, Chen, Yongchun
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6902237535
FWCI:
Cites:
Cited by:
Related to: