Additional file 4 of Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse
Year: 2025
Type: article
Abstract: Additional file 4: Figure S1. Representative heart sections for infarct size assessment by histological TTC staining and quantification of TTC-stained infarcts. Gelsenicine increased myocardial hypoxia-ischemia injury in the mice. NMDA and glycine preconditioning attenuated the damage induced by gelsenicine and improved cardiac function. Mice in gelsenicine groups received an i.p. injection of 0.24 mg/kg gelsenicine, control mice were injected with normal saline. Mice in the Glycine/NMDA + Gelsenicine groups were pre-treated with either 1600 mg/kg glycine or 25 mg/kg NMDA, respectively, prior to receiving the identical dose of 0.24 mg/kg gelsenicine. Data are represented as mean ± SD. *** P < 0.001, ****P < 0.0001 based on one-way ANOVA or unpaired t tests. n=3 mice/group.
Source: Figshare
Authors: Huang, Chong-Yin, Zuo, Meng-Ting, Qi, Xue-Jia, Gong, Meng-Die, Xu, Wen-Bo, Meng, Si-Yu, Long, Jiang-Yu, Li, Pi-Shun, Sun, Zhi-Liang, Zheng, Xiao-Feng, Liu, Zhao-Ying
Institution: Hunan Agricultural University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6902239063
FWCI:
Cites:
Cited by:
Related to: