A previously undescribed 3,4-secodammarane derivative from Ailanthus altissima
Year: 2025
Type: article
Abstract: A new 3,4-secodammarane derivative (1) was obtained from the bark of Ailanthus altissima. The combination of spectral analysis and the computation of electronic circular dichroism (ECD) has definitively confirmed the absolute configuration of the compound. This configuration has been identified as methyl (20S, 24 R)-epoxy-25-hydroxy-3,4-secodammar-4(28)-en-29-al-3-oate. Furthermore, Compound 1 exhibited notable inhibitory effects on two specific cancer cell lines: the MDA-MB-231 and the SW620. The calculated IC50 values for these cell lines were found to be 23.02 and 20.88 μM, respectively, indicating a significant potential for this compound in therapeutic applications against these types of cancer.
Source: Figshare
Authors: Yu-Sha Shi, Li-Lian Zhao, Li Huang, Su Hu, De-Feng Peng, Zhuo-Hong Li, Yun Deng, Da-Le Guo
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6902243064
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