Additional file 4 of African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity
Year: 2025
Type: article
Abstract: Additional file 4. ASFV MGF505-4R potentiates PRV-GFP replication. (A and B) HEK293T cells were transfected with increasing doses of His-MGF505-4R plasmid, along with pGL3-IFN-β-Luc and pRL-TK, for 24 h and then infected with 0.1 MOI of PRV-GFP for 24 h before luciferase assays, western blot detection and fluorescence microscope observation. (C and D) SK6 cells were treated in the same manner as described for HEK293T cells for luciferase assays, western blot detection, and fluorescence microscope observation. n = 3; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ns, not significant.
Source: Figshare
Authors: Yao, Manman, Li, Pengfei, Li, Xiangmin, Li, Wentao, Qian, Ping
Institution: Huazhong Agricultural University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6902250505
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