Two new monoterpene glycosides from the endophytic fungus Diaporthe nobilis and their cytotoxic effects
Year: 2025
Type: article
Abstract: Two new monoterpene glycosides, diaporthosides A (1) and B (2), were purified from Diaporthe nobilis, an endophytic fungus isolated from the medicinal plant Polygonatum odoratum. Their structures were determined by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was assigned by comparing its experimental ECD spectrum with the calculated spectrum using quantum-chemical ECD calculations. In addition, compounds 1 and 2 were evaluated for cytotoxic activity against the HGC-27 cancer cell line, with compound 1 exhibiting moderate activity (IC50 = 46.93 ± 1.06 μM).
Source: Figshare
Authors: Ying Chen, Jian Wang, Cai-Lin Zhao, Xiu-Feng Yang, Jin Ye, Lin-Ping Zhang, Yun-Xiao Li, Fan-Wei Liu, Le Zhang, Bo Song
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6902253486
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