Additional file 1 of Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks
Year: 2025
Type: article
Abstract: Additional file 1: Legends for Supplementary Figures and Tables. Fig. S1: Schematics of the histone modification signatures associated with various enhancer activity states. Fig. S2: Examples of Primed, Poised, and Non-primed hNPC enhancers. Fig. S3: Relative proportions of specific and non-specific lineage enhancer states. Fig. S4: Comparisons between ePrimed and ePoised human lineage-specific enhancer subgroups. Fig. S5: hESC H3K4me1 levels correlate with hESC H2K27ac levels at ePrimed enhancers. Fig. S6: Identification of mEND enhancer subgroups. Fig. S7: Genes associated with mECT and mEND enhancers. Fig. S8: Fetal and Somatic expression of ePrimed enhancer associated genes. Fig. S9: E11.5 mForebrain enhancers overlapping VISTA annotated enhancers. Fig. S10: Additional epigenetic profiling of fetal brain enhancers and DNA methylation of ePrimed enhancers within DNMT/TET KOs and gastrulation. Fig. S11: ePrimed enhancer associated gene network analysis. Fig. S12: Identification of human late-embryonic liver and kidney ePrimed enhancers. Fig. S13: Identification of mouse E11.5 liver and heart ePrimed enhancers. Fig. S14: Conservation of mouse and human ePrimed enhancers and associated genes. Fig. S15: Dynamics of ePrimed upon a cell fate transition into an alternative lineage. Fig. S16: DNA hypomethylation of ePrimed enhancers within somatic tissues. Fig. S17: ePrimed 7pcw fetal brain enhancers within HipSci donor lines.
Source: Figshare
Authors: Christopher D. Todd, Jannat Ijaz, Fereshteh Torabi, Oleksandr Dovgusha, Stephen Bevan, Olivia Cracknell, Tim Lohoff, Stephen Clark, Ricard Argelaguet, Juliette Pearce, Ioannis Kafetzopoulos, Alice Santambrogio, Jennifer Nichols, Ferdinand von Meyenn, Ufuk Günesdogan, Stefan Schoenfelder, Wolf Reik
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6902257248
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