Effect of immuno-oncology on clinical and economic outcomes for a selection of cancers in Italy
Year: 2025
Type: article
Abstract: This study assesses the impact of immune-oncology (IO) drugs’ availability on cancer incidence-adjusted mortality rates from melanoma, lung, and renal cancers at population level in Italy between 2008 and 2019. We conducted a retrospective study on cross-sectional time-series aggregated data collected from publicly available sources and IQVIA proprietary databases. Three fixed-effects regression models were used to estimate how IO availability affects incidence-adjusted mortality for each cancer type. Estimated deaths were compared with deaths in a scenario with no IO drugs availability. Finally, the number of averted deaths was valued using the human capital approach. A 1% increase in IO availability reduces incidence-adjusted mortality rates for melanoma, lung, and renal cancers by 0.125% (95% CI: 0.138–0.112; p < 0.01), 0.011% (95% CI: 0.013–0.009; p < 0.01) and 0.005% (95% CI: 0.006–0.003; p < 0.01) between the introduction of the drug in the therapeutic area and 2019. This reduction resulted in total savings of € 49.0 million, € 61.3 million, and € 10.9 million in indirect costs due to premature mortality, respectively. IO drugs introduction in Italy between 2008 and 2019 was associated with a significant decrease in deaths from each cancer and, consequently, in savings in indirect costs related to premature mortality.
Source: Figshare
Authors: Canali, Beatrice, Apolone, Giovanni, Ascierto, Paolo A., De Braud, Filippo, Grossi, Francesco, Perrone, Francesco, Fiorentino, Francesca, Di Costanzo, Alessandra, Candelora, Laura, Patanè, Giovanni, Zapparelli, Giuseppina, Mezzanotte, Claudia, Didoni, Guido, Riccaboni, Massimo
Language: English
Subfield: Economics and Econometrics
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W6902260107
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