Acronyculatin S, a polyphenolic isoprenylated acetophenone benzofuran with antibacterial properties from the flowers of Acronychia pedunculata
Year: 2025
Type: article
Abstract: Phytochemical investigation of the flowers of Acronychia pedunculata led to the isolation of eight compounds. They consist of one undescribed polyphenolic isoprenylated acetophenone benzofuran, acronyculatin S (1), and seven known compounds: demethylacrovestone (2), acrovestone (3), acroflavone A (4), 3,5,4′-trihydroxy-3′,8-dimethoxy-7-(3-methylbut-2-enyloxy)flavone (5), xanthotoxin (6), isopimpinellin (7) and N-methylflindersine (8). The structures of the isolated compounds were elucidated by thorough analysis of spectroscopic (IR, NMR and ECD) and spectrometric (MS) data. Compounds 1 and 2 were tested against seven bacterial strains. They displayed significant activities against methicillin-resistant Staphylococcus aureus and Bacillus subtilis with MIC values in the range of 2–8 µg/mL.
Source: Figshare
Language: English
Topic: Bioactive natural compounds
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6902263692
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