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Additional file 2 of Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice

Year: 2025

Type: article

Abstract: Supplementary Material 2: Supplementary Fig. 2 The L19-targeted antibody specifically hits EDB-FN1 of human tumor tissues. L19-targeted antibody in IgG1 format specifically target EDB-FN1 (Green) in human PDAC tumor tissues, while KSF antibody (specific for hen egg lysozyme, an irrelevant antigen) was used as negative CTR.

Source: Figshare

DOI: 10.6084/m9.figshare.28157708

Authors: Carbone, Carmine, De Luca, Roberto, Puca, Emanuele, Agostini, Antonio, Caggiano, Alessia, Priori, Lorenzo, Esposito, Annachiara, Ascrizzi, Serena, Piro, Geny, Salvatore, Lisa, De Sanctis, Francesco, Ugel, Stefano, Corbo, Vincenzo, Neri, Dario, Tortora, Giampaolo

Institutions: Agostino Gemelli University Polyclinic, Philochem (Switzerland), Università Cattolica del Sacro Cuore, University of Verona, ETH Zurich, Philogen (Italy)

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6902270273

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