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Additional file 6 of An antibody-drug conjugate targeting soluble and membrane-bound TGFα is effective against pancreatic tumors

Year: 2025

Type: dataset

Abstract: Supplementary Material 6: Fig. 6. Internalization of anti-TGFα-MMAF antibodies in pancreatic cancer cell lines. Capan-1 cells were treated for 12 hours at 37°C with 2.5 nM of 5F1-MMAF or 16B10-MMAF, with or without prior incubation with 50 µM of chloroquine (Ch), 3 hours before. White dots indicate colocalization between the anti-TGFα ADCs and LAMP1, which is represented by scatter graphs at the bottom. Scale: 25 µm. Anti-TGFα ADCs: red, LAMP1: green; DAPI: blue.

Source: DIGITAL.CSIC (Spanish National Research Council (CSIC))

DOI: 10.6084/m9.figshare.29143087

Authors: Romero-Pérez, Inés, Montero, Juan Carlos, Redondo-Puente, Mónica, del Carmen Gómez-García, María, Morell-Ginestà, Mireia, Capellá, Gabriel, Pandiella, Atanasio

Institutions: Centro de Investigación del Cáncer, Instituto de Investigación Biomédica de Salamanca, Institut Català d'Oncologia, Centro de Investigación Biomédica en Red de Cáncer

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6902274333

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