Quality by design-based method to synthesize sulfonamides using LiOH.H2O
Year: 2025
Type: article
Abstract: A rapid, systematic and optimized process for the synthesis of sulfonamides was developed using lithium hydroxide monohydrate (LiOH.H2O) as a base. The study employed a response surface methodology (RSM) approach using a central composite design (CCD) to determine the ideal reaction conditions, specifically base equivalence and temperature. A series of 13 experimental runs identified the most efficient conditions as 0–5°C with 0.5 equivalents of LiOH.H2O, resulting in very good to excellent yields within 1–8 min. The optimized reaction parameters significantly reduced reaction time while maintaining high selectivity and yield. Compared to conventional base-mediated sulfonamide synthesis, this approach minimizes excess reagent usage, enhances reaction efficiency, and supports sustainable synthetic methodologies.
Source: Figshare
Authors: Bait, Sahil P., Gurjar, Archana S.
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6902277739
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