Three bioactive dibenzocyclooctadiene lignans from the fruits of Kadsura coccinea
Year: 2025
Type: article
Abstract: Three new dibenzocyclooctadiene lignans, namely, kadcolignan H-J (1–3), were isolated from the ethanol extract of Kadsura coccinea fruits. Their molecular structures, including absolute configurations, were elucidated through comprehensive spectroscopic analyses. The hepatoprotective effects of kadcolignan H-J (1–3) were subsequently evaluated. Both kadcolignan H (1) and kadcolignan J (3) demonstrated inhibitory effects on triglyceride and total cholesterol levels, whereas all isolated compounds effectively reduced the levels of free fatty acids-induced reactive oxygen species in HepG2 cells.
Source: Figshare
Authors: Wen-Ming Wu, Jian Liu, Chao Chen, Bao-Lin Wang, An Jin
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6902288862
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