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Two new dibenzyl-γ-butyrolactone lignans with cytotoxic activity from Himalaiella heteromalla, an Indian Himalayan plant

Year: 2025

Type: article

Abstract: Two new (−)-parairesinol (3), lappaol G (5), and three known (1, 2, and 4) dibenzyl-γ-butyrolactone lignans were isolated from the Indian Himalayan herb Himalaiella heteromalla. Their structures were characterised by NMR and mass data analysis. In vitro cytotoxic study revealed that arctiin (4) showed promising growth inhibition across seven human cancer cells, with potent activity against Mia-PaCa-2 cells. Notably, compounds 3 and 5 did not demonstrate significant cytotoxicity up to 80 μM concentrations.

Source: Figshare

DOI: 10.6084/m9.figshare.29040201

Authors: Bikram Singh, Chandan Thappa, Komal, Perumahanthi Laasya Priya, Safeya Begum, Yedukondalu Nalli, Boobalan Gopu

Language: English

Topic: Plant-derived Lignans Synthesis and Bioactivity

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6902344033

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