Synthesis, crystal structure and evaluation of antibacterial activity of new hybrid systems containing furan-2-one and chromen-4-thione fragments
Year: 2025
Type: article
Abstract: A series of new hybrid systems containing furan-2-one and chromen-4-thione fragments were synthesized for the first time and characterized by elemental analysis, IR, NMR (1H,13C, NOESY) spectroscopy and X-ray structural analysis. It was shown that (E)-5-aryl-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-ones exist only in the E-configuration. Their in vitro antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was studied in liquid nutrient media by the serial dilution method. The results showed that (E)-5-(4-chlorophenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one and (E)-5-(4-methoxyphenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one demonstrated the best in vitro antibacterial properties against the bacterial culture Escherichia coli.
Source: Figshare
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6902350129
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