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Additional file 3 of Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC

Year: 2025

Type: article

Abstract: Supplementary Material 3: Fig. 3. Analysis of deep RNA sequencing data for MDA-MB-231 cells treated with 1 µM T-025. (A) PPIs analysis on downregulated genes related to cell migration. (B) The top 10 most important hub genes of the PPIs identified by CytoHubba in Cytoscape based on MCC algorithm. (C) The top 20 GO cellular components terms enriched in downregulated genes. (D) PPI network of the downregulated genes involved in focal adhesion

Source: Figshare

DOI: 10.6084/m9.figshare.29671194

Authors: Liu, Nasi, van der Velde, Jurjun J. S., Ramdjielal, Sherien, Koedoot, Esmee, van Overbeek, Nila K., Batenburg, Daisy, Vertegaal, Alfred C. O., van de Water, Bob, Le Dévédec, Sylvia E.

Institutions: Leiden University, Leiden University Medical Center

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6902402011

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