A novel strategy for the efficient synthesis of Erianin
Year: 2025
Type: article
Abstract: Erianin, a natural biphenyl compound found in Dendrobium, exhibits significant pharmacological effects, including anti-tumor and anti-inflammatory properties. Here, we report a novel and efficient three-step synthetic route for Erianin, utilizing homovanillic acid and 3,4,5-trimethoxybenzaldehyde as starting materials. Our method integrates hydroxyaldehyde condensation, microwave-assisted decarboxylation, and mild double bond reduction, achieving a total yield of 45.3%—a 47.7% improvement over prior approaches. The developed protocol provides a cost-effective and scalable approach to access Erianin, offering significant potential for therapeutic research and drug development.
Source: Figshare
Authors: Zhang, Wenpei, Pan, Xinyue, He, Jie, Lin, Yirong, Zhang, Fengyang, Guo, Li, Liu, Jieqing
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6902413240
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