Orientin: a natural glycoside with versatile pharmacological activities
Year: 2025
Type: article
Abstract: Orientin is one of the flavonoid glycosides with diverse biological properties such as anticancer, antioxidant, neuroprotective, cardioprotective, antiallergic, and anti-inflammatory. It is found in several plants like rooibos tea, Ocimum sanctum, Trollius, Passiflora, and Phyllostachys species. This review aimed to summarise the various medicinal properties of the orientin focusing on its underlying molecular mechanism reported based on in-vitro and in-vivo studies. The data were collected using various search engines, incorporating PubMed/Medline, Scopus, Science Direct, Google Scholar, Web of Science, and SpringerLink. Our findings showed that orientin exhibited promising anticancer, neuroprotective, anti-inflammatory, and antioxidant activities. Hopefully, this information could assist drug researchers and pharmaceutical entities in finding an effective herbal drug for the treatment of different disorders with potential mechanisms of action. Meanwhile, further investigations are warranted such as oral bioavailability, pharmacokinetics and pharmacodynamic characteristics of orientin to establish fully drug profiling suitable for clinical trials.
Source: Figshare
Authors: Ishaq, Ali Raza, El-Nashar, Heba A. S., Al-Qaaneh, Ayman M., Asfandyar, Bashir, Aneela, Younis, Tahira
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6902423067
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