Synthesis, Characterization, Insecticidal Activities, and in Silico Molecular Docking Study of Some New Norfloxacin Analogues Based on 5-Spiro-1,2,4-Thiadiazoles
Year: 2025
Type: article
Abstract: The significant problems with the use of pesticides have made the use of safe substitutes essential. Consequently, families of new, ecologically safe norfloxacin series that are effective in killing insects were found using 5-substituted 1,2,4-thiadiazoles. If the thiadiazole ring were isosterically added to the norfloxacin ring, more potent biological activity and/or a greater variety of sap-feeding bugs were anticipated. The target synthesized compounds will undergo both modern elemental and characterization analyses (IR,1H NMR,13C NMR) to confirm their structure. The second category involved testing the generated chemicals on Aphis gossypii, the cotton aphid, nymphs, and adults. The most impacted synthetic chemical, compound 1, had an LC50 of 0.907 mg/L, according to the available information, whereas the LC50 of commercial thiacloprid was 0.255 mg/L. Molecular docking studies confirmed these findings, with compounds 1, 4, 7, and 10 displaying significantly stronger binding affinities to the hydrolase enzyme (−7.90, −7.70, −7.80, −7.70 kcal/mol) compared to the reference compound thiacloprid.
Source: Figshare
Authors: El‑Saghier, Ahmed M., Abosella, Laila, Abdellattif, Magda H., Gad, Mohamed A.
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
SDG: Zero hunger
Open Access status: green
OpenAlex ID: W6902430116
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