Biochemical profiling and anticancer properties of brown seaweed Dictyota dichotoma (Hudson.) J.V.Lamouroux
Year: 2024
Type: article
Abstract: In the present study, we have extracted the secondary metabolites from Dictyota dichotoma and evaluated their anticancer properties against Michigan Cancer Foundation-7 (MCF-7) breast cancer cell lines. Different solvent extracts were used to isolate the bioactive molecules form D. dichotoma. Among them, methanol extract showed the highest total phenol content (TPC: 306.31 ± 1.7 GAE mg/g extract), total tannin content (TTC: 291.90 ± 1.2 RE mg/g extract) and total flavonoid content (TFC: 92.89 ± 0.6 GAE mg/g extract). The antioxidant ABTS assay of methanol extract inhibited 74.51 ± 0.10% of free radicals and phosphomolybdenum assay showed 62.36 ± 0.04 mg/g AAE/g extract. Furthermore, bioactive compounds were characterised by gas chromatography-mass spectroscopy (GC-MS), highly performance liquid chromatography (HPLC) and Fourier transmission infrared spectroscopy (FT-IR). The GC-MS results revealed 29 bioactive compounds that are highly potential biological activities. The extracted compound was quantified and confirmed by HPLC and FT-IR. The D. dichotoma methanol extract effectively induced the apoptosis in MCF-7 breast cancer cells and recorded IC50 value of 44.35 ± 8.62 µg/mL.
Source: Trends in Phytochemical Research
Authors: Arputhaswamy, Velankanni, Rajkumar, Vasanthkumar, Thomas, Nancy Mary, Sathasivam, Vinoth, Muthukrishnan, Arun, Packiaraj, Gurusaravanan
Institutions: Bharathiar University, Sona College of Arts and Science
Language: English
Subfield: Aquatic Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W6902671063
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