Chemical constituents of the roots and rhizomata of Torricellia angulata var. intermedia
Year: 2024
Type: article
Abstract: Torricellia angulata var. intermedia belongs to the genus Torricellia. In China, this plant is mainly found in Guangxi, Guizhou, Yunnan and Sichuan. T. angulata var. intermedia has been prescribed for the treatment of various diseases in the field of traditional Chinese medicine, such as rheumatoid arthritis, closed soft-tissue injuries. In order to study the chemical constituents of the roots and rhizoma of T. angulata var. intermedia. This paper explored the chemical constituents of 45% ethanol extraction of T. angulata var. intermedia by D101 macroporous resin, silica gel, preparative high performance liquid chromatography and other methods. Their structures were elucidated by extensive spectroscopic analysis such as 1D-NMR, 2D-NMR, HR-ESI-MS and so on. The absolute configurations were determined by comparison of the experimental and theoretically calculated ECD. The results were as follows: Fifteen compounds were isolated and identified as(7S,8S)-8,9-dihydroxy-3,5,7-trimethox phenicol-4-O-β-D-glucoside(1), adenosine(2),(8E)-decaene-4,6-diyn-1-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside(3), 2,6-dimethoxy-p-benzoquinone(4), palmiticacid(5), 2,2'-oxybis(1,4-di-tert-butylbenzene)(6), syringaldeyde-4-O-β-D-glucopyranoside(7), phytol(8), p-hydroxybenzaldehyde(9),(8R)-deca-2-trans-2-ene-4,6-diyn-1,8-diol(10), nicotinamide(11), aralidioside(12), β-daucosterol(13), griselinoside(14), 2-(4-hydroxy-3-methoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-3-oxo-1-propanol(15). Among them, 1 was a new compound, 2-4, 6, 7, 9-12 and 15 were isolated from Toricellia for the first time. The results of this study enrich the phytochemical information of T. angulata var. intermedia, and provide a material basis for the elucidation of its pharmacodynamic substances, the search for quality markers, the exploration of pharmacological mechanisms and the development of drugs.
Author: ZHU Banghui1,3, NIE Yushan1,3, LI Xue1,3, LIU Chunhua1, LI Yueting2, MA Xue1 , LI Yongjun1,2,3*
Institution: Guiyang Medical University
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6903578287
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