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Kinetic Resolution of BINOLs and Biphenols by Atroposelective, Cu–H-Catalyzed Si–O Coupling with Hydrosilanes

Year: 2024

Type: article

Abstract: A nonenzymatic kinetic resolution of monoprotected BINOL and biphenol derivatives by atroposelective Si–O coupling with hydrosilanes is described. The reaction relies on a previously unprecedented Cu–H-catalyzed silylation of phenols. The catalyst system consisting of CuCl, ( R , R )-Ph-BPE, and NaO t Bu enables the enantioselective coupling of the phenolic hydroxy group with a hydrosilane with moderate to good selectivity factors.

Source: DepositOnce

DOI: 10.14279/depositonce-22128

Authors: Böser, Lisa A., Oestreich, Martin

Language: English

Topic: Axial and Atropisomeric Chirality Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W6904695641

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