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Antibacterial Activity of Some Non-steroidal Anti-inflammatory Drugs against Proteus mirabilis

Year: 2024

Type: article

Abstract: In some recent investigations, non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol demonstrated antibacterial action. This study aimed to evaluate the inhibitory effects of diclofenac, piroxicam, and paracetamol against multidrug-resistant Proteus mirabilis. The sensitivity of Proteus spp. was tested for nine antibiotics representing seven different families using an agar diffusion test. The isolates with multiple antibiotic resistances were selected to test the effect of NSAIDs and paracetamol on growth using a resazurin-based microplate broth dilution assay. The findings of the agar diffusion test revealed the highest level of antibiotic resistance for Proteus isolates was recorded against ceftazidime with a percentage of (91.53%) followed by amoxicillin-clavulanate and cefixime (81.36%) and (76.27%), respectively. The isolates were resistant to azithromycin at a rate of (69.49%). Furthermore, moderate resistance was observed among the isolates to levofloxacin (66.10%), gentamicin (55.93%), and aztreonam (47.46%). While the lowest resistance was reported (18.64%) against piperacillin-tazobactam and (8.47%) against imipenem, Imipenem had the greatest antibacterial activity (88%); also, NSAIDs showed distinct antibacterial activity against Proteus mirabilis in (2500, 5000 μg/ml) and above concentrations for piroxicam and diclofenac, respectively. Paracetamol failed to show antibacterial activity against Proteus mirabilis

Source: Ibn AL- Haitham Journal For Pure and Applied Science

DOI: 10.30526/37.4.3495

Authors: Ghena Jameel Ibrahim, Bahaa Abdullah Laftaah AL-Rubaii

Institution: University of Baghdad

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: University of Baghdad