A Review Article on Drug Selection Criteria for TDDS
Year: 2024
Type: article
Abstract: Transdermal drug delivery systems (TDDS), sometimes known as “patches,” are dosage forms designed to disperse a therapeutically active dose of medication across a patient’s skin in order to create systemic effects. Transdermal drug delivery devices are used to administer medications topically. These are pharmacological preparations of different sizes that include one or more active compounds. They are meant to be administered topically to the intact skin and prevent first pass metabolism by delivering the active component after it has passed through the skin barriers. Currently, 74% of medications are taken orally and are not as effective as intended. Transdermal medication delivery systems were developed to increase efficacy. With TDDS, the medication enters the skin and travels to the target spot with ease. Transdermal drug delivery devices were created as a solution to the issues with oral medication administration. Since 1981, these systems have been used as trustworthy and safe drug delivery methods. Due to hepatic first pass metabolism and the propensity to cause both high and low blood level spikes, the typical oral dose forms have substantial downsides. These include poor bioavailability, which necessitates high and/or frequent dosing, which can be both expensive and inconvenient. Transdermal drug delivery systems (TDDS) have been developed to address these issues. By delivering medications to particular sites within the body, TDDS can reduce dosage size and increase safety while also improving therapeutic efficacy. TDDS is one such delivery method that has been thoroughly investigated with positive treatment outcomes during the past 25 years. TDDS is the perfect treatment for conditions that require ongoing care. Compared to the traditional oral dosing type, topical medication delivery has numerous benefits. The restriction of hepatic metabolism, improvement of therapeutic efficacy, and preservation of the drug's constant plasma level are significant benefits of TDDS.
Author: Anuradha Magar, Ulka Mote
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6911668104
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